Are calcium silicate sealers less cytotoxic and genotoxic than epoxy resin sealers? A systematic review of in vitro studies.

Authors

  • Vinícius Souza Eilers Department of Endodontics, School of Dentistry, Rio Grande do Sul Federal University (UFRGS), Porto Alegre, RS, Brazil.
  • Theodoro Weissheimer Department of Endodontics, School of Dentistry, Rio Grande do Sul Federal University (UFRGS), Porto Alegre, RS, Brazil.
  • Lina Naomi Hashizume Department of Preventive and Social Dentistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Jefferson Ricardo Pereira Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, SC, Brazil.
  • Gabriel Barcelos Só Department of Endodontics, School of Dentistry, Rio Grande do Sul Federal University (UFRGS), Porto Alegre, RS, Brazil.
  • Ricardo Abreu da Rosa Department of Endodontics, School of Dentistry, Rio Grande do Sul Federal University (UFRGS), Porto Alegre, RS, Brazil.
  • Marcus Vinícius Reis Só Department of Endodontics, School of Dentistry, Rio Grande do Sul Federal University (UFRGS), Porto Alegre, RS, Brazil.

DOI:

https://doi.org/10.59306/jrd.v11e220231-19

Keywords:

Calcium silicate, Citotoxicity, Epoxy resin, Genotoxicity, Systematic review

Abstract

Aims: This systematic review aimed to evaluate whether calcium silicate-based sealers are less cytotoxicity and genotoxicity than epoxy resin-based sealers.

Materials and Methods: Systematic searches were conducted for studies published up to September 27th, 2022, without restriction for language or year of publication, in the following databases: MEDLINE/PubMed, Scopus, Web of Science and Grey Literature Report. Only in vitro studies that evaluated the cytotoxicity or genotoxicity of calcium silicate and epoxy resin-based sealers were included. The quality assessment was performed.

Results: After duplicate removal and eligibility criteria assessment, a total of thirty-four studies were included. Twenty-eight studies had a low risk of bias, and six studies had a moderate risk of bias. In general, calcium silicate-based sealers had a lower cytotoxic and genotoxic potential than epoxy-resin based sealers.

Conclusions: Based on the findings from in vitro studies, calcium silicate-based sealers are less cytotoxic and genotoxic than epoxy resin-based sealers.

Downloads

Published

2023-09-11

Issue

Vol. 11 No. 2 (2023)

Section

Articles

License

Copyright (c) 2023 Journal of Research in Dentistry

Creative Commons License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

CC Attribution-NonCommercial-NoDerivatives 4.0