Influence of MMP inhibitors on bond strength of adhesive system: systematic review and meta-analysis

Abstract

Objectives: This systematic review with meta-analysis aimed to evaluate the effect of metalloproteinase (MMPs) inhibitors on in vitro bond strength using initial (24 hours) and long-term (6, 12 months or longer) microtensile tests.

Sources: A search was carried out in 7 databases and in the gray literature, limited to Portuguese, English and Spanish languages ??without publication year limit, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) 2009.

Study selection: Only in vitro studies assessing the use of MMP inhibitors in adhesive procedures were included (Kappa = 0.86). Meta-analyses were conducted with the extracted data and the studies were evaluated for quality. Data: Of 5,134 potentially eligible studies, 112 were selected for full-text reading, 48 were reviewed, and 43 were included in the meta-analysis. Two independent evaluators selected the studies and assessed the risk of bias. Estimates of the combined effect were reported as means ??and standard deviation between groups. Conclusion: The use of 2% CHX affected positively the initial bond strength, but no inhibitor was effective in maintaining the bond strength after the aging process.